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We then discuss how distinct tumour metabolic phenotypes, characterized by high glycolysis, amino acid dependency or lipid dysregulation, generate local environmental stresses that differentially reprogram DC function and T cell fitness

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Other common symptoms of B12 deficiency include: Lethargy or a total lack of energy Extreme fatigue Palpitations Pale skin Feeling faint Breathlessness Weight loss and loss of appetite Your doctor may prescribe B12 injections in extreme cases that take effect right away